Industry Investigator Position

GlaxoSmithKline

Pennsylvania
Posted 4 months ago
​The Novel Human Genetics Research Unit (NHG RU) at GlaxoSmithKline (GSK) was recently formed to identify and advance novel targets with human genetic association to disease. The NHG RU is therapeutically broad and complements other research units with strategic focus in immunology and oncology.  The remit of the NHG RU is to identify and validate novel targets, develop assets and implement early clinical proof of mechanism and proof of concept studies.

We are currently seeking a laboratory-based scientist to conduct integrative physiology/pharmacology experiments that drive the discovery of medicines. The scientist will support preclinical efforts for target validation, lead optimization and may also support clinical programs. Apply online at gsk.wd5.myworkdayjobs.com/GSKCareers/job/…

The key responsibilities and attributes of the individual filling this role are detailed below.

Key Responsibilities:

  • Recommendation and delivery of in vivo physiology/pharmacology experiments primarily in rodents to support drug discovery programs across multiple therapeutic areas (i.e. neuroscience, cardiovascular, liver, kidney, metabolism)
  • Generate hypotheses, develop methods, design and implement integrative studies, analyze and present results
  • Interpret results and draw conclusions through independent working and with supervision
  • Problem-solve technical challenges and deliver results efficiently
  • Effective communication (both verbal and written) of scientific ideas and results to teams
  • Work independently as well as in a matrix environment
  • Work under supervision with opportunity to develop greater independence

Accountability:

  • Accountable for conducting in vivo experiments and recording studies in accordance with GSK best practices
  • Be a self-starter, with good organizational skills, and with a strong inclination to immerse in both the science and execution of in vivo physiology/pharmacology studies
  • Work in a manner to ensure scientific accuracy, integrity, and robustness of the data collected
  • Accountable for own safety, safety of the team, and welfare of animals.
  • With support from management, accountable for your own continued development as a drug discovery scientist
  • Work and behave in compliance with GSK values and code of conduct at all times

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

  • Ph.D. in physiology, pharmacology, or related biology field
  • At least one year of postdoctoral experience
  • Exposure to a range of in vivo biology methods and techniques including those for neurodegeneration, cardiovascular function, liver disease, renal disease, inflammation, and/or metabolism
  • Experience leading and running in vivo studies in rodents including dosing, formulation, tissue harvest, and blood sampling.
  • Proficiency with Microsoft Office software and maintaining laboratory notebooks
  • Excellent analytical, problem-solving, communication, and organizational skills

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

  • Demonstrated scientific accomplishment and independence
  • Knowledge and experience in multiple in vivo models to probe disease relevant mechanisms for neurodegeneration, cardiovascular dysfunction, liver dysfunction, renal dysfunction, and/or metabolism
  • The individual should have evidence of recent learning on the job and application of their new skill.
  • Good graphing and statistical analysis skills including use of GraphPad Prism.
  • Publication track record consistent with years of experience
  • Industry drug discovery experience

Why GSK?

Our values and expectations are at the heart of everything we do and form an important part of our culture.

These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:

  • Operating at pace and agile decision-making – using evidence and applying judgement to balance pace, rigor and risk.
  • Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  • Sustaining energy and well-being.
  • Building strong relationships and collaboration, honest and open conversations.
  • Budgeting and cost-consciousness.

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Christine Schnackenberg PhD
Director
GlaxoSmithKline
Collegeville PA
(610) 270-6720
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Apply Online